Publications
Dr. Yang has written over 160 publications, including over 90 as first-, co-first or senior author. Dr. Yang is an editorial board member of the Journal of Thoracic and Cardiovascular Surgery, the Journal of Thoracic Diseases, and the Society of Thoracic Surgeons Online Curriculum. He is also an associate editor for Pearson’s General Thoracic Surgery.
Highlighted Manuscripts:
15 most recent publications:
chi-fu jeffrey yang chi-fu jeffrey yang: Latest results from PubMed
- Outcomes After Surgical Management of Early-Stage Lung Cancer in Octogenarians: An in-depth Analysis of a Nationally Representative Cohortby Ian C Bostock on January 30, 2025 at 11:00 am
CONCLUSIONS: This analysis provides an updated and expanded characterization of age-related outcomes based on a large national cohort representative of elderly patients treated outside of clinical trials. Substantial gaps in survival and discharge disposition motivate further research and the development of interventions to help improve outcomes in older patients.
- Assessing Lung Cancer Screening Eligibility of Lung Cancer Patients in the Boston Lung Cancer Study: An Analysis of 7,186 Lung Cancer Casesby Alexandra L Potter on January 26, 2025 at 11:00 am
CONCLUSIONS: In this analysis of 7,186 lung cancer patients, only 46.1% would have met the USPSTF criteria. Including a smoking duration criterion and removing the 15-years-since-quitting criterion from the USPSTF guideline would increase the proportion of patients eligible for screening.
- The Impact of Food Insecurity on the Management and Survival of Stage I-III Esophageal Cancerby Marianna V Papageorge on January 10, 2025 at 11:00 am
CONCLUSIONS: Among patients with esophageal cancer, significant disparities in surgical resection and survival are associated with high county-level food insecurity. Interventions focused on these communities may help reduce inequities in esophageal cancer care.
- The 2021 US Preventive Services Task Force lung cancer screening eligibility criteria disproportionately exclude younger Black patients with lung cancerby Alexandra L Potter on December 11, 2024 at 11:00 am
CONCLUSIONS: This analysis of SCCS participants with lung cancer found that the 2021 USPSTF eligibility criteria disproportionately exclude many younger Black individuals with lung cancer, primarily because they have too few smoking pack-years.
- Optimal Treatment Strategies for Early-Stage Primary Mediastinal Germ Cell Tumorsby Margaret E Yang on November 8, 2024 at 11:00 am
CONCLUSIONS: In this national analysis, multimodality treatment involving surgery was associated with improved survival compared with chemotherapy alone for early-stage primary mediastinal nonseminomatous germ cell tumors. For seminomas of the mediastinum, chemotherapy was associated with similar long-term outcomes compared with multimodality treatment involving surgery.
- Primary lung signet-ring cell carcinoma: a national analysisby Arian Mansur on October 24, 2024 at 10:00 am
CONCLUSIONS: In this national analysis, LSRCC was found to be associated with distinct clinicopathological characteristics from those of LAC.
- Salvage lung resection after immunotherapy is feasible and safeby Attila Nemeth on September 19, 2024 at 10:00 am
CONCLUSIONS: Lung resection after immunotherapy appears to be a feasible salvage treatment option, with lobectomy being most common and with high R0 resection rates. Low patient morbidity and mortality rates also suggest the safety of this approach. Salvage surgery may be considered in patients who have oligo-progression after immunotherapy within the context of a comprehensive multidisciplinary treatment plan.
- Comparative effectiveness of perioperative physical activity in older adults with lung cancer and their family caregivers: design of a multicenter pragmatic randomized trialby Virginia Sun on August 8, 2024 at 10:00 am
BACKGROUND: With a median age at diagnosis of 70, lung cancer remains a significant public health challenge for older Americans. Surgery is a key component in treating most patients with non-metastatic lung cancer. These patients experience postoperative pain, fatigue, loss of respiratory capacity, and decreased physical function. Data on quality of life (QOL) in older adults undergoing lung cancer surgery is limited, and few interventions are designed to target the needs of older adults and…
- Safety and Optimizing Ergonomics for Cardiothoracic Surgeonsby Shivaek Venkateswaran on June 29, 2024 at 10:00 am
Cardiothoracic surgery, demanding in nature, often results in surgeons suffering from musculoskeletal injuries, causing chronic pain and leading to premature retirement. A significant majority report experiencing pain, exacerbated by minimally invasive techniques such as video-assisted thoracoscopic surgery. Despite this, many surgeons delay seeking medical assistance. To mitigate these risks, preventative strategies such as strength exercises, stretching during operations, and taking brief…
- Act1 drives chemoresistance via regulation of antioxidant RNA metabolism and redox homeostasisby Lingzi Hong on June 11, 2024 at 10:00 am
The IL-17 receptor adaptor molecule Act1, an RNA-binding protein, plays a critical role in IL-17-mediated cancer progression. Here, we report a novel mechanism of how IL-17/Act1 induces chemoresistance by modulating redox homeostasis through epitranscriptomic regulation of antioxidant RNA metabolism. Transcriptome-wide mapping of direct Act1-RNA interactions revealed that Act1 binds to the 5’UTR of antioxidant mRNAs and Wilms’ tumor 1-associating protein (WTAP), a key regulator in m6A…
- Early Detection and Interception of Lung Cancerby Allison E B Chang on May 9, 2024 at 10:00 am
Recent advances in lung cancer treatment have led to dramatic improvements in 5-year survival rates. And yet, lung cancer remains the leading cause of cancer-related mortality, in large part, because it is often diagnosed at an advanced stage, when cure is no longer possible. Lung cancer screening (LCS) is essential for intercepting the disease at an earlier stage. Unfortunately, LCS has been poorly adopted in the United States, with less than 5% of eligible patients being screened nationally….
- Wedge Resection versus Stereotactic Body Radiation Therapy for Non-Small Cell Lung Cancer Tumors ≤8 mmby Arian Mansur on March 27, 2024 at 10:00 am
The objective of this study was to evaluate the overall survival of patients with ≤8 mm non-small cell lung cancer (NSCLC) who undergo wedge resection versus stereotactic body radiation therapy (SBRT). Kaplan-Meier analysis, multivariable Cox proportional hazards modeling, and propensity score-matched analysis were performed to evaluate the overall survival of patients with ≤8 mm NSCLC in the National Cancer Database (NCDB) from 2004 to 2017 who underwent wedge resection versus patients who…
- Pack-Year Smoking History: An Inadequate and Biased Measure to Determine Lung Cancer Screening Eligibilityby Alexandra L Potter on March 27, 2024 at 10:00 am
CONCLUSION: Use of a 20-year smoking duration cutoff instead of a 20-pack-year cutoff greatly increases the proportion of patients with lung cancer who would qualify for screening and eliminates the racial disparity in screening eligibility between Black versus White individuals; smoking duration has the added benefit of being easier to calculate and being a more precise assessment of smoking exposure compared with pack-year smoking history.
- The International Association for the Study of Lung Cancer (IASLC) Staging Project for Lung Cancer: Recommendation to Introduce Spread Through Air Spaces as a Histologic Descriptor in the Ninth Edition of the TNM Classification of Lung Cancer. Analysis of 4061 Pathologic Stage I NSCLCby William D Travis on March 20, 2024 at 10:00 am
CONCLUSIONS: These data support our recommendation to include STAS as a histologic descriptor for the Ninth Edition of the TNM Classification of Lung Cancer. Hopefully, gathering these data in the coming years will facilitate a thorough analysis to better understand the relative impact of STAS, LVI, and VPI on lung cancer staging for the Tenth Edition TNM Stage Classification.
- A Pilot Study Using Machine-learning Algorithms and Wearable Technology for the Early Detection of Postoperative Complications After Cardiothoracic Surgeryby Jorind Beqari on March 14, 2024 at 10:00 am
CONCLUSIONS: Machine-learning analysis of biometric data collected from wearable devices has the potential to detect postoperative complications-before symptom onset-after cardiothoracic surgery.